Mice (小鼠/大鼠）

brain (大脑）

· Li B, Li L, Li M, Lam SM, Wang G, Wu Y, Zhang H, Niu C, Zhang X, Liu X, Hambly C, Jin W, Shui G, Speakman JR. Microbiota Depletion Impairs Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue. Cell Rep. 2019, 26(10):2720-2737.

· Lam S M, Wang R, Miao H, et al. An integrated   method for direct interrogation of sphingolipid homeostasis in the heart and   brain tissues of mice through postnatal development up to reproductive   senescence[J]. Analytica Chimica Acta, 2018.

· Chan R B, Oliveira T G, Cortes E P, et al. Comparative lipidomic analysis of mouse and human brain with Alzheimer disease.[J]. Journal of Biological Chemistry, 2012, 287(4):2678-88. 

· Lim W L, Lam S M, Shui G, et al. Effects of a high-fat, high-cholesterol diet on brain lipid profiles in apolipoprotein E ε3 and ε4 knock-in mice.[J]. Neurobiology of Aging, 2013, 34(9):2217-2224.

· Long N N, Ma D, Shui G, et al. Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid[J]. Nature, 2014, 509(7501):503.

· Jenner A M, Lim W L F, Ng M P E, et al. The effect of APOE, genotype on brain levels of oxysterols in young and old human APOE, ε2, ε3 and ε4 knock-in mice[J]. Alzheimers & Dementia the Journal of the Alzheimers Association, 2010, 6(4):S255-S256.

· Oliveira T G, Chan R B, Tian H, et al. Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits[J]. Journal of Neuroscience the Official Journal of the Society for Neuroscience, 2010, 30(49):16419-28.

· Lee L H, Shui G, Farooqui A A, et al. Lipidomic analyses of the mouse brain after antidepressant treatment: evidence for endogenous release of long-chain fatty acids?[J]. Int J Neuropsychopharmacol, 2009, 12(7):953-964.

· Sharman M J, Shui G, Fernandis A Z, et al. Profiling brain and plasma lipids in human APOE epsilon2, epsilon3, and epsilon4 knock-in mice using electrospray ionization mass spectrometry.[J]. Journal of Alzheimers Disease Jad, 2010, 20(20):105-11.

· Zhang F, Wang Y, Wang T, Yao L, Lam SM, Huang X, Fan J, Wang Q, Liu L, Jiang Y, Zhang H, Shi L, Yu M, Shui G, Wang Y, Gao F, Zhang X, Xu Z.  cTAGE5/MEA6 plays a critical role in neuronal cellular components trafficking and brain development. PNAS. 2018, 115(40):E9449-E9458.

brain/prefrontal cortex

前额皮质

· He P, Hou B, Li Y, Xu C, Ma P, Lam SM, Gil V, Yang X, Yang X, Zhang L, Shui G, Song J, Qiang G, Liew CW, Du G. Lipid Profiling Reveals Browning Heterogeneity of White Adipose Tissue by Β3-Adrenergic Stimulation. Biomolecules. 2019, 9,444

· Ee S M, Lo Y L, Shui G, et al. Distribution of secretory phospholipase A2 XIIA in the brain and its role in lipid metabolism and cognition[J]. Molecular Neurobiology, 2014, 50(1):60-75.

· Lee H W, Tan C H, Lo Y L, et al. Brain lipid changes after repetitive transcranial magnetic stimulation: potential links to therapeutic effects?[J]. Metabolomics, 2012, 8(1):19-34.

brain/cortical neurons 

皮质神经元

· Zhao Feng Peng, Minghui Jessica Chen, Manikandan J, et al. Multifaceted role of nitric oxide in an  in vitro  mouse neuronal injury model: transcriptomic profiling defines the temporal recruitment of death signalling cascades[J]. Journal of Cellular & Molecular Medicine, 2012, 16(1):41-58.

· Sundaram J R, Chan E S, Poore C P, et al. Cdk5/p25-induced cytosolic PLA2-mediated lysophosphatidylcholine production regulates neuroinflammation and triggers neurodegeneration.[J]. Journal of Neuroscience, 2012, 32(3):1020-1034.

brain/nigrostriatal 

黑质纹状体

· Lim L, Jacksonlewis V, Wong L C, et al. Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease[J]. Cell Death & Differentiation, 2012, 19(3):416.

brain/caudal medulla oblongata

尾髓延髓

· Ma M T, Yeo J F, Shui G, et al. Systems wide analyses of lipids in the brainstem during inflammatory orofacial pain - evidence of increased phospholipase A(2) activity.[J]. European Journal of Pain, 2012, 16(1):38-48.

brain/hippocampus

海马区

· Lee H W, Tan C H, Lo Y L, et al. Brain lipid changes after repetitive transcranial magnetic stimulation: potential links to therapeutic effects?[J]. Metabolomics, 2012, 8(1):19-33.

brain/striatum

纹状体

· Lee H W, Tan C H, Lo Y L, et al. Brain lipid changes after repetitive transcranial magnetic stimulation: potential links to therapeutic effects?[J]. Metabolomics, 2012, 8(1):19-33.

heart 心脏

· Lam S M, Wang R, Miao H, et al. An integrated method for direct interrogation of sphingolipid homeostasis in the heart and brain tissues of mice through postnatal development up to reproductive senescence[J]. Analytica Chimica Acta, 2018.

· Yu D L E, Yung L Y L, Ong C N, et al. Translocation and effects of gold nanoparticles after inhalation exposure in rats[J]. Nanotoxicology, 2007, 1(3):235-242.

livers 肝脏

•  

  • Zhang C, Hao CJ, Shui G, Li W. BLOS1 mediates kinesin switch during endosomal recycling of LDL receptor. eLife, (2020).

  • Shi YP, Lam SM, Liu H, Luo GH, Zhang J, Yao S, Li J, Zheng L, Xu N, Zhang XY, Shui G. Comprehensive lipidomics in apoM-/- mice reveals an overall state of metabolic distress and attenuates hepatic lipid secretion into the circulation. JGG, (2020).

  • Wei L, Yue FZ, Xing L, Wu SY, Shi Y, Li J, Xiang XW, Lam SM, Shui G, Russell R, Zhang DM. Constant light exposure alters gut microbiota and promotes the progression of steatohepatitis in high fat diet rats. Frontiers in Microbiology. (2020).

  • Hou BY, He P, Ma P, Yang XY, Xu CY, Lam SM, Shui G, , Xiuying Yang , Zhang L, Qiang GH, Du GH. Comprehensive Lipidome Profiling of the Kidney in Early-Stage Diabetic Nephropathy. Frontiers in Endocrinology. (2020).

  • Li XW, Shi Z, Zhu YW, Shen TY, Wang HY, Shui G, Juan J. Loor, Fang, Meng Chen ZY,  Wang XH, Peng ZC, Song YX, Wang Z, Du XL, Liu GW. Cyanidin‐3‐O‐glucoside improves non‐alcoholic fatty liver disease by promoting PINK1‐mediated mitophagy in mice. British Journal of Pharmacology, 2020.doi:10.1111.

  • Li, R., Wang, Y., Hou, B., Lam, S.M., Zhang, W., Chen, R., Shui, G., Sun, Q., Qiang, G., Liu, C.,Lipidomics insight into chronic exposure to ambient air pollution in mice.Environmental Pollution. 2020 Apr 23. dio: 10.1016.

  • Li R, Sun Q, Lam SM, Chen R, Zhu J, Gu W, Zhang L, Tian H, Zhang K, Chen LC, Sun Q, Shui G*, Liu C*. Sex-dependent effects of ambient PM2.5 pollution on insulin sensitivity and hepatic lipid metabolism in mice. Part Fibre Toxicol. 2020 Apr 22;17(1):14.

  • Li X, Shi Z, Zhu Y, Shen T, Wang H, Shui G, Loor JJ, Fang Z, Chen M, Wang X, Peng Z, Song Y, Wang Z1, Du X, Liu G. Cyanidin-3-O-glucoside improves non-alcoholic fatty liver disease by promoting PINK1-mediated mitophagy in mice. Br J Pharmacol. 2020 (in press) doi: 10.1111.

  • Wu L,Zhang X,Zheng L,Zhao H,Yan G,Zhang Q,Zhou Y,Lei J,Zhang J,Wang J,Xin R,Jiang L,Peng J,Chen Q,Lam SM,Shui G,Miao H,Li Y. RIPK3 Orchestrates Fatty Acid Metabolism in Tumor-Associated Macrophages and Hepatocarcinogenesis. Cancer Immunol Res.2020 Mar 2. doi: 10.1158.

  • Yue, F., Xia, K., Wei, L., Xing, L., Wu, S., Shi, Y., … Zhang, D. Constant light exposure causes dysregulation of sphingolipids and promotes steatohepatitis in high‐fat fed rats. Journal of Gastroenterology and Hepatology. 2020, dio: 10.1111

  • Hou, B., Zhao, Y., He, P., Xu, C., Ma, P., Lam, S. M., … Du, G. Targeted lipidomics and transcriptomics profiling reveal the heterogeneity of visceral and subcutaneous white adipose tissue. Life Sciences, 2020.117352.

  • Shi, J.-H., Lu, J.-Y., Chen, H.-Y., Wei, C.-C., Xu, X., Li, H., … Zhang, W. J. Liver ChREBP Protects Against Fructose-induced Glycogenic Hepatotoxicity by Regulating L-type Pyruvate Kinase. Diabetes, 2020.db190388.

  • Che L, Chi W, Qiao Y, Zhang J, Song X, Liu Y, Li L, Jia J, Pilo M8, Wang J, Cigliano A, Ma Z, Kuang W, Tang Z, Zhang Z, Shui G, Ribback S, Dombrowski F, Evert M, Pascale RM, Cossu C, Pes GM, Osborne TF, Calvisi DF Chen X, Chen L. Cholesterol biosynthesis supports the growth of hepatocarcinoma lesions depleted of fatty acid synthase in mice and humans. Gut. 2019, doi: 10.1136.

  • Su X, Liu S, Zhang X, et al. Requirement of cytosolic phospholipase A2 gamma in lipid droplet formation[J]. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2017, 1862(7):692-705.

  • Yaligar J, Gopalan V, Kiat O W, et al. Evaluation of dietary effects on hepatic lipids in high fat and placebo diet fed rats by in vivo MRS and LC-MS techniques.[J]. Plos One, 2014, 9(3):e91436.

  • Rodriguez-Navarro J A, Cuervo A M. Inhibitory effect of dietary lipids on chaperone-mediated autophagy.[J]. Autophagy, 2012, 109(7):E705-14.

  • Wang Y, Liu L, Zhang H, et al. Mea6 controls VLDL transport through the coordinated regulation of COPII assembly.[J]. Cell Research, 2016, 26(7):787-804.

     

lung 肺

· Jin J, Li Y, Ren J, et al. Neonatal Respiratory Failure with Retarded Perinatal Lung Maturation in Mice Caused by Reticulocalbin 3 Disruption[J]. Am J Respir Cell Mol Biol, 2016, 54(3):410-423.

· Shui G, Bendt A K, Jappar I A, et al. Mycolic acids as diagnostic markers for tuberculosis case detection in humans and drug efficacy in mice[J]. Embo Molecular Medicine, 2012, 4(1):27-37.

plasma 血浆

· Ma J, Wang R, Lam SM, Zhang C, Shui G*, Li W*. Plasma lipidomic profiling in murine mutants of Hermansky-Pudlak syndrome reveals differential changes in pro- and anti-atherosclerotic lipids. Biosci Rep. 2019, 39(2): BSR20182339.

· Long N N, Ma D, Shui G, et al. Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid[J]. Nature, 2014, 509(7501):503.

· Yu D L E, Yung L Y L, Ong C N, et al. Translocation and effects of gold nanoparticles after inhalation exposure in rats[J]. Nanotoxicology, 2007, 1(3):235-242.

· Sharman M J, Shui G, Fernandis A Z, et al. Profiling brain and plasma lipids in human APOE epsilon2, epsilon3, and epsilon4 knock-in mice using electrospray ionization mass spectrometry.[J]. Journal of Alzheimers Disease Jad, 2010, 20(20):105-11.

· Ma J, Wang R, Lam SM, Zhang C, Shui G, Li W. Plasma lipidomic profiling in murine mutants of Hermansky-Pudlak syndrome reveals differential changes in pro- and anti-atherosclerotic lipids. Biosci Rep. 2019, doi: 10.1042.

sebaceous glands 

皮脂腺

· Zhang S, Shui G, Wang G, et al. Cidea Control of Lipid Storage and Secretion in Mouse and Human Sebaceous Glands[J]. Molecular & Cellular Biology, 2014, 34(10):1827-1838.

adipose 脂肪组织

· Liang XJ, Tao C, Pan JF, Zhang LI,Liu L, Zhao Y, Fan YP, Cao CW,Liu JL, Zhang J, Lam SM, Shui G, Jin WZ, Li W, Zhao JG, Li K, Wang YF. Rnf20 deficiency in adipocyte impairs adipose tissue development and thermogenesis. Protein & Cell. (2020).

· Lin-Hu Quan, Chuanhai Zhang, Meng Dong, Jun Jiang, Hongde Xu, Chunlong Yan, Xiaomeng Liu, Huiqiao Zhou, Hanlin Zhang, Li Chen, Fei-Liang Zhong, Zhao-Bo Luo, Sin-Man Lam, Guanghou Shui, Donghao Li, Wanzhu Jin. Myristoleic acid produced by enterococci reduces obesity through brown adipose tissue activation. Gut. 2019, doi:10.1136

· Liu L, Jiang Q, Liu G. Abstract 406: Adipose-Specific Deletion of SEIPIN/BSCL2 Results in Progressive Lipodystrophy[J]. Arterioscler Thromb Vasc Biol, 2014.

· Si X, Shang W, Zhou Z, et al. Gama-aminobutyric Acid Enriched Rice Bran Diet Attenuates Insulin Resistance and Balances Energy Expenditure via Modification of Gut Microbiota and SCFAs.[J]. Journal of Agricultural & Food Chemistry, 2018, 66(4).

· Liu Z, Lim C Y, Su M Y, et al. Neonatal overnutrition in mice exacerbates high-fat diet-induced metabolic perturbations.[J]. Journal of Endocrinology, 2013, 219(2):131-43.

· Li TY, Song L, Sun Y, Li J, Yi C, Lam SM, Xu D, Zhou L, Li X, Yang Y, Zhang CS, Xie C, Huang X, Shui G, Lin SY, Reue K, Lin SC. Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate. Nat Commun.2018, 15;9(1):1916.

· Li B, Li L, Li M, Lam SM, Wang G, Wu Y, Zhang H, Niu C, Zhang X, Liu X, Hambly C, Jin W, Shui G, Speakman JR. Microbiota Depletion Impairs Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue. Cell Rep. 2019, 26(10):2720-2737.

embryonic fibroblasts 

胚胎成纤维细胞

· Tan S H, Shui G, Zhou J, et al. Critical role of SCD1 in autophagy regulation via lipogenesis and lipid rafts-coupled AKT-FOXO1 signaling pathway.[J]. Autophagy, 2014, 10(2):226-242.

· Tan S H, Shui G, Zhou J, et al. Induction of autophagy by palmitic acid via protein kinase C-mediated signaling pathway independent of mTOR (mammalian target of rapamycin).[J]. Journal of Biological Chemistry, 2012, 287(18):14364-76.

· Wu Y T, Tan H L, Shui G, et al. Dual Role of 3-Methyladenine in Modulation of Autophagy via Different Temporal Patterns of Inhibition on Class I and III Phosphoinositide 3-Kinase[J]. Journal of Biological Chemistry, 2010, 285(14):10850-10861.

· Siddique M M, Bikman B T, Wang L, et al. Ablation of dihydroceramide desaturase confers resistance to etoposide-induced apoptosis in vitro.[J]. Plos One, 2012, 7(9):e44042.

muscles 肌肉

· Holland W L, Bikman B T, Wang L P, et al. Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid–induced ceramide biosynthesis in mice[J]. Journal of Clinical Investigation, 2011, 121(5):1858-70.

· Bikman B T, Guan Y, Shui G, et al. Fenretinide Prevents Lipid-induced Insulin Resistance by Blocking Ceramide Biosynthesis[J]. Journal of Biological Chemistry, 2012, 287(21):17426-17437.

· Summermatter S, Shui G, Maag D, et al. PGC-1α Improves Glucose Homeostasis in Skeletal Muscle in an Activity-Dependent Manner[J]. Diabetes, 2013, 62(1):85-95.

mammary gland 

乳腺

· Wang W, Lv N, Zhang S, et al. Cidea is an essential transcriptional coactivator regulating mammary gland secretion of milk lipids[J]. Nature Medicine, 2012, 18(2):235.

Intestine  肠道

· Liu RQ, Qiao SH, Shen WS, Liu Y, Lu Y, Huang LY, Guo Z, Gong JF, Shui G, Li Y, Zhu WM. Disturbance of Fatty Acid Desaturation Mediated by FADS2 in Mesenteric Adipocytes Contributes to Chronic Inflammation of Crohn’s Disease. J Crohns Colitis. 2020. DOI: 10.1093/ecco-jcc/jjaa086.

· Li B, Li L, Li M, Lam SM, Wang G, Wu Y, Zhang H, Niu C, Zhang X, Liu X, Hambly C, Jin W, Shui G, Speakman JR. Microbiota Depletion Impairs Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue. Cell Rep. 2019, 26(10):2720-2737.